Antithrombin alfa
ATryn (antithrombin alfa) is a protein pharmaceutical. Antithrombin alfa was first approved as Atryn on 2006-07-28. It has been approved in Europe to treat antithrombin III deficiency.
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Indications
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| antithrombin iii deficiency | HP_0001976 | D020152 | D68.59 |
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Clinical
Clinical Trials
88 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Antithrombin iii deficiency | D020152 | HP_0001976 | D68.59 | 2 | 4 | 5 | 2 | 4 | 16 |
| Thrombosis | D013927 | — | — | 1 | 1 | 2 | 2 | 6 | 11 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 2 | 2 | — | 1 | 2 | 7 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | 1 | 1 | 2 | 1 | 3 | 7 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | — | 2 | 1 | — | 3 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | 1 | — | 2 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 1 | 1 | — | 2 |
| Cardiac surgical procedures | D006348 | — | — | — | 1 | — | 1 | — | 2 |
| Thrombophilia | D019851 | — | D68.59 | — | — | — | 1 | 1 | 2 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | — | 1 | — | 1 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | 1 | 1 | — | 9 | 10 |
| Hemostatic disorders | D020141 | — | — | — | 1 | 1 | — | 9 | 10 |
| Cardiopulmonary bypass | D002315 | — | — | 2 | 1 | 1 | — | — | 4 |
| Disseminated intravascular coagulation | D004211 | HP_0005521 | D65 | — | 1 | 3 | — | — | 4 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | 1 | — | 1 | — | 1 | 3 |
| Extracorporeal membrane oxygenation | D015199 | — | — | — | 1 | 1 | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | 1 | — | — | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | 1 | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | 1 | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | — | 2 | — | — | 3 | 5 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | — | — | 3 | 4 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | 1 | — | — | 2 | 4 |
| Wounds and injuries | D014947 | — | T14.8 | — | 2 | — | — | — | 2 |
| Syndrome | D013577 | — | — | — | 1 | — | — | 1 | 2 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 2 | — | — | — | 2 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | 1 | — | — | 1 | 2 |
| Thromboembolism | D013923 | HP_0001907 | — | — | 1 | — | — | 1 | 2 |
| Fibrosis | D005355 | — | — | 1 | 1 | — | — | — | 2 |
| Ischemia | D007511 | EFO_0000556 | — | — | 1 | — | — | — | 1 |
Show 14 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | 1 | — | — | — | 1 | 2 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | — | — | — | 1 | 2 |
| Postoperative hemorrhage | D019106 | — | — | 1 | — | — | — | 1 | 2 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Toxemia | D014115 | — | — | — | — | — | — | 3 | 3 |
| Coagulation protein disorders | D020147 | — | — | — | — | — | — | 2 | 2 |
| Congenital disorders of glycosylation | D018981 | — | — | — | — | — | — | 2 | 2 |
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 1 | 1 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | — | 1 | 1 |
| Sclerosis | D012598 | — | — | — | — | — | — | 1 | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 1 | 1 |
| Hemolysis | D006461 | — | — | — | — | — | — | 1 | 1 |
| Hemolytic anemia | D000743 | — | D55-D59 | — | — | — | — | 1 | 1 |
Show 34 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Antithrombin alfa |
| INN | antithrombin alfa |
| Description | Antithrombin-III precursor (ATIII) (PRO0309) |
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201554 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | AWV6I5L6H2 (ChemIDplus, GSRS) |
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17 adverse events reported
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